Nanoparticles Kill Cancer

Nanoparticles Kill Cancer Nanoparticles Kill Cancer Nanoparticles Kill CancerOf the more than 200 types of krebs that threaten the human organism, lung cancer is the deadliest. Its responsible for some 27 percent of all cancer deaths, and less than 20 percent of those diagnosed with the disease will beat it. The attempt to do so usually involves chemotherapy, radiation, or lobectomy, all of which come with difficult side effects. Now theres some hope that the nearly half-million people with lung cancer could some day be treated with an inhaler and a few magnets. The key to the possible treatment is the superparamagnetic iron oxide nanoparticle. Jayanth Panyam, a professor in the Department of Pharmaceutics at the University of Minnesota, has shown in lab work with rats and mice how the method would work. Patients would first suck the nanoparticles into their lungs. Then, they would be surrounded by an oscillating magnetic field, which would heat up the particles. If you can localize these particles in or next to the wulst cells then you can heat the exkreszenz cells and then they die, he says. Panyam proved the effectiveness of the technique by injecting nanoparticles into tumors in mice. When he subsequently put the mice inside of a small magnetic coil and turned on the juice, he successfully killed tumor cells. To get the particles to where they need to be, and away from healthy cells, the nanoparticles would likely be attached to peptides that would attach onto tumors. Then you would have a more selective tumor cell kill, says Panyam. The heat given off by the particles dissipates within mere microns, so nearby healthy cells will, for the most part, remain unscathed. The hope is that, yes, you may have some nonspecific distribution to the healthy cells, but if the concentrations are not high enough you wouldnt induce enough heat to kill the cells, he says. Tumor growth in each group of mice monitored over four weeks after nanoparticle-induced magnetic hypert hermia treatment. Image Jayanth Panyam As of now, the technique attacks only the surface of a tumor. Panyams lab is working on creating a protein cocktail that would help the particles shoot through the tumor matrix. But however deep such nano drills might penetrate, theyre not likely to extinguish a tumor entirely on their own. This would probably not be a stand-alone treatment, says Panyam. Panyams most recent paper shows that the way the cells die depends on the size of the particles. Researchers had thought the magnetically heated particles killed cells by inducing hyperthermia, a slow fasson of death, he says. But Panyam found that larger aggregates of nanoparticles were killing tumor cells in an entirely different manner. The oscillating magnetic field was causing the particles to actually move. The heat coming from the particles wasnt what was killing the cells. Instead, the particles were literally ripping open the cell membrane. These micron-sized aggregates actually induce necrosis, the more violent form of death, says Panyam. The finding was so surprising that Panyam and his colleagues thought perhaps the larger particles were heating up more and perhaps burning a hole through cell membranes. But when they put the particles and cells in a cool bath, they found that when hit with the magnetic field, they killed the cells in the same way. In cancer that might actually be more beneficial. Necrosis can stimulate an immune response, and that is more effective in eliminating tumor growth, says Panyam. Whatever the size of the particles and how they do their killing, the technique might not be limited to inhalation and lung cancer. When the surgeon goes in and cuts out the tumor, you could introduce the particles right on the site of the tumor, Panyam says. With the right proteins, and afew more studies, it may someday be the smallest particles that take down one of the biggest killers. Michael Abrams is an independent writer. Learn more at ASME 2015 4th G lobal Congress on NanoEngineering for Medicine and Biology For Further DiscussionIf you can localize these particles in or next to the tumor cells then you can heat the tumor cells and then they die.Prof. Jayanth Panyam, University of Minnesota

Veterans

VeteransUniform Regulations For Air Force Retirees / VeteransWhether you are retired Air Force or served and now classify as a veteran of the Air Force, there are rules to where, when and how you can wear the uniform and medals and ribbons on civilian clothing. Naturally the retired member is granted more frequency to wearing the uniform but only for certain occasions. A retired member of the military are granted many privileges to active military bases, stores and tafelgeschirrs, as well as receives a pension and medical / dental benefits. Typically to achieve this level of privilege, one much serve for at least 20 years, however being medically retired due to injury or illness is another way to receive similar benefits as a retired member in the military. These members also qualify for the following uniform authorizations The Rules for Retirees Air Force retirees may wear the uniform under the following circumstances Formal Settings - Events such as military ceremonies,funeral s, weddings, memorial services, and inaugurals are all appropriate places to wear the uniform. Traveling to and from any of these functions as well as the ones listed below while in uniform is permitted however the travel while in uniform must be less that 24 hours of the event starting time. Holiday Events - There are many days where the uniform of the military retiree is appropriately worn. Holidays such as the Fourth of July, Memorial Day, and Veterans Day on other such events as patriotic parades when military units are participating or being honored. Educational Institutions - When part of giving military instructions or responsible for military discipline the retiree may also take part and observe while in uniform. Social Events or other functions when the invitation to the event is because of the retired service members prior service and acquaintances related to that service. Air Force retirees may wear any of the uniform as prescribed at date of retirement according to Air F orce Instruction 36-2903. Retirees should wear the retirement lapel button on the left lapel. Retired Airmen receive the retired lapel button at retirement. If the retired Airmen was in command at the squadron, group or wing level can wear the command insignia pin on the left lapel, below the retired lapel button. Senior Enlisted retirees whose last assignment before retirement was a first sergeant and/or command chief may wear appropriate chevrons in all instances the uniform is worn The Rules for Veterans A veteran is defined by a prior military service member who served honorably in any of the branches of the military and Coast Guard (Army, Navy, Air Force, Marines) as an officer of enlisted. Discharged Veterans. Veterans who served honorably (this includes honorable and general discharges) in the Air Force (including service with an air component of the Army before the Air Force was established), during a declared or undeclared war, may wear the uniform Formal Settings- Even ts such as military ceremonies,funerals, weddings, memorial services, and inaugurals are all appropriate places to wear the appropriate uniform. Traveling to and from any of these functions as well as the ones listed below while in uniform is permitted however the travel while in uniform must be less that 24 hours of the event starting time. Holiday Events- There are many days where the uniform of the military retiree is appropriately worn. Holidays such as the Fourth of July, Memorial Day, and Veterans Day on other such events as patriotic paradeswhen military units are participating or being honored. And any other event required by law.Separated Airmen (regardless of whether or not they served during a time of war) may wear the uniform from place of discharge to home, within 3 months after discharge. Medal of Honor Recipients TheMedal of Honor is obviously special and the recipients deserve the benefits and may wear the uniform at any time except the following events or situat ions Public or Political Speeches - Participating in public speeches, interviews, picket lines, marches or rallies, or in any public demonstration when the Air Force sanction of the cause for which the activity is conducted may be implied. Personal or Political Gain - The MOH recipient may notfurther political activities, private employment, or commercial interests wearing the medal and / or the uniform. Civilian Employment - MOH recipients may not wear the medal while working in an off-duty civilian capacity. Civil or Criminal Court - The MOH recipient may not wear the medal while participating in civilian court proceedings when the conviction would bring discredit to military service. Note Any individual wearing a US Military uniform is expected to reflect the high personal appearance standards and esprit de studentencorps that the US Military in uniform represent. To this end, particular attention will be paid not only to the correct and military wear of uniform components, but a lso to the individuals personal and physical appearance. All personnel exercising the privilege of wearing a US Military uniform will comply fully with their services grooming and weight control standards. Air Force Instruction 36-2903addresses the wear of Air Force uniforms by Air Force retirees and Air Force veterans.

8 Ways to Transform Your Job Search in 2018

8 Ways to Transform Your Job Search in 20188 Ways to Transform Your Job Search in 2018 The New Year gives all of us an opportunity for a do-overand who doesnt love a do-over? If 2017 wasnt the best year for your career-wise, of if youre planning a career or job change for 2018, the New Year is here to give you the opportunity to transform your job search.Its time to say goodbye to any resume mistakes , words you misspoke in an interview , or phone interviews that didnt go well in 2017. If youre leaving your current company, its time to move on to brighter and better things.If youre looking to revolutionize your job search process in the New Year, here are the steps you should take to really make 2018 the year you land your dream job.First things first if you want to find your dream job, you need to make sure you understand what your dream job is. To do so, you need to spend a little time understanding what you like to do and how that fits in with your career g oals.If youre looking for your dream job, I definitely recommend prioritizing your personal development in 2018, says Laura Weldy, life coach at The Well Supported Woman . Really pay attention to not just the careers that sound fun, but what about each role is interesting to you. The more self-aware you are the easier it will be to find a role that fulfills you. To achieve this step, Weldy suggests focusing on actionable personal goals, such as reading personal development podcasts or listening to creative-inspiring podcasts weekly. Resolutions of that type help to expand your world, and along with the expanded world come expanded opportunities, says Weldy.With the New Year ahead, its time to set resolutions for yourself. If youre not normally the type to set resolutions, you should consider giving it a try this year to help you transform your job search. You dont need to set personal goals if you dont want to, but, rather, you should think about some of the mistakes you made in yo ur job search last yearand use those to help you determine what you can and should do differently this year.Make a short list of the top actionable things you think you can do better in your job search this year. Some resolutions might be attend at least one networking event each month until you land your dream job work with a resume writer or mentor to re-vamp your resume research your salary so you can identify your worth and earn what you truly deserve or expand your professional network and determine if you know anyone who works at your dream company.One of the biggest mistakes job seekers make during the job search is going into it blindly. If you have no idea what kind of jobs are available in your city, or how much money people earn in the position you are hoping to land, you might be drumherum yourself up to be let down. Instead of doing the same-old, same-old for your job hunt process, consider transforming the way you approach looking for a job by doing your research ahe ad of time. Make a list of the companies you know about and would love to work for. Then, research companies with a similar mission or product to expand your options of working in the industry. You should also research the companies you are interested ahead of time to make sure it still sounds like a distributions-mix you would even want to work at. Moreover, theres no point in applying to a job that you know is not going to pay you fairlyso make sure you Know Your Worth and only apply to positions that will value your experience. If you struggled in your job search last year, or if youre nervous about the big career leaps you plan to take in 2018, its important to know you dont have to go through this process alone. If youre having trouble sticking to the goals you set for yourself, you might need a hand from someone who either understands how you operate, or is professionally trained to motivate you out of a rut.This is when working with a professional life coach comes in hand y, says Weldy. A life coach is essentially a project manager for the creation of your fullest, best life they exist to help you clarify what you want to create, hold you accountable to those goals regularly, and assist you in dissecting any blocks to your success that get in the way.A mentor can come in the form of a life coach, career coach, friend, family member , or even your current manager. If you have previously done your job search completely on your own, the biggest change you could make this year could be just asking someone to help youSpeaking of bringing others into your job search have you ever spent time at your friends or family members place of work? If you know someone who absolutely loves what they doand especially if you know someone who works at your dream companyconsider asking if you can visit them at work.If the job search has you down or youre worried that youll never find your dream job , maybe you need a little inspiration to help you revolutionize your process. By going to see someone you know work in a healthy, friendly environment and seeing how they are both treated by their co-workers, and how passionate they are to show you what they do for a living, youll gain a better understanding of what it means to have a job you truly love. And once you know what it looks like to have your dream jobyou wont stop until you get it Looking for a job is stressful . Its easy to get bogged down by having to re-write your resume or constantly write cover lettersand when you never hear back from anyone, it can drive you a little insane.But, the problem job seekers make is that they spend all their time looking for a job and never take a break from the search. We understand that you dont want to waste any time because you need to pay your billsbut if you dont take a moment to de-stress and breathe, youre only making the process that much harder for yourself.When you feel you are reaching a high-stress point in your job search , take a day or tw o off. And I mean really take the day offif you can afford to take a short trip, do so. If you are low on funds, simply relax at home (away from computer screens) or go for a walk around your neighborhood. Youll be surprised at how refreshing taking even just one day away from the actual search will help you re-set and re-prioritize your process. It might not sound like fun, but there are ways to make your job process enjoyable You dont have to be miserable while you do thisin fact, approaching your job search in that mindset is probably hurting your applications because its hindering your passion from shining through.I would encourage you to have fun with this process, and not to take it too seriously, advises Weldy. Its important to have goals and resolutions, because they tell us where to focus our attention in a world thats full of distractions. Some of them will change over time, and thats part of our development as individuals.Lastly, the best thing you can do for yourself t o revolutionize your job search is to make sure you are setting clear intentions for yourself. Remember you are on your side with this, so you dont need to be too hard on yourself, and you dont want to set yourself up for failure.The beauty is in the learning and growing that comes from setting clear intentions and overcoming our own obstacles, says Weldy. Even if the goal isnt completed at the end of 2018, youll feel proud of the progress youve made in that direction but if you set no goals or resolutions, its harder to know which direction youre headed